1059734-66-5

1059734-66-5

添加时间:2017-12-05 15:46:00


CAS No.1059734-66-5

LAL IDxqy-170103

Chemical Names:    BMS-833923; 1059734-66-5

Molecular Formula: C30H27N5O

Molecular Weight:   473.58 g/mol

Purity: 98%

Description:

Oral, small molecule antagonist of the Hedgehog (Hh) signaling component Smoothened (SMO). Treatment with BMS 833923 leads to a decreased expression of GLI1 and PTCH1 in EGI-1 cells, reduced tumor growth in vitro, and a prolongation of survival in vivo in different human cancers. Additionally, SMO inhibition by BMS 833923 leads to decreased proliferation and induces apoptosis in esophageal adenocarcinoma cells (EACs).


上一个:957485-64-2