1059734-66-5
添加时间：2017-12-05 15:46:00
CAS No.：1059734-66-5
LAL ID：xqy-170103
Chemical Names: BMS-833923; 1059734-66-5
Molecular Formula: C30H27N5O
Molecular Weight: 473.58 g/mol
Purity: 98%
Description:
Oral, small molecule antagonist of the Hedgehog (Hh) signaling component Smoothened (SMO). Treatment with BMS 833923 leads to a decreased expression of GLI1 and PTCH1 in EGI-1 cells, reduced tumor growth in vitro, and a prolongation of survival in vivo in different human cancers. Additionally, SMO inhibition by BMS 833923 leads to decreased proliferation and induces apoptosis in esophageal adenocarcinoma cells (EACs).
