356559-20-1
添加时间：2017-12-05 15:55:00
CAS No.：356559-20-1
LAL ID：xqy-170107
Chemical Names: 356559-20-1; SB 525334; 6-(2-(tert-Butyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline
Molecular Formula: C21H21N5
Molecular Weight: 343.434 g/mol
Purity: 98%
Description:
Potent and selective inhibitor of the ALK5 receptor (IC50 value 14.3 nM). SB 525334 is approximately 4-fold less potent as an inhibitor of ALK4, and inactive as an inhibitor of ALK2, ALK3, and ALK6. In cell-based assays, SB 525334 blocked TGF-β1-induced phosphorylation and nuclear translocation of Smad2/3 in renal proximal tubule cells and inhibited TGF-β1-induced increases in plasminogen activator inhibitor-1 (PAI-1) and procollagen alpha1(I) mRNA expression in renal epithelial carcinoma cells.
